By the way safe mode is a troubleshooting mode for any windows application to open the application with minimum configuration. But here we have discussed about, how to fix outlook application that keeps opening up in safe mode. To fix outlook opens in safe mode as an issue in windows machine, follow the below steps.
- Open registry editor by typing regedit.msc in search bar below in your windows machine.
- Open registry editor as administrator as shown below. Make sure outlook is closed.

- Navigate to: Computer\HKEY_CURRENT_USER\SOFTWARE\MICROSOFT\OFFICE\14.0\OUTLOOK\RESILIENCY
- Right click on RESILIENCY and delete as show below.RESILIENCY

- Launch outlook
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